|Objectives||The purpose of this study is to evaluate the efficacy and safety of bevacizumab combined with paclitaxel as first or second line chemotherapy in clinical practice in HER2 negative inoperable or metastatic breast cancer patients.|
|Endpoints||Primary outcomes: Overall Survival(OS)
Secondary outcomes: Response Rate(RR), Progression Free Survival(PFS), Safety
|Trial Period||5 years 2012.11.1 - 2017.10.31|
|Lead Principal Investigator||1)Yutaka Yamamoto,Kumamoto University Hospital
2)Hiroyasu Yamashiro, National Hospital Organization Kure Medical Center and Chugoku Cancer Center
|No. of Institutions|
|Target Sample Size||750（cohort A:500, cohort B:250）|
|Regimen||bevacizumab combined with paclitaxel|
|Source of Funding||Chugai Pharmaceutical Co., Ltd.|
|Articles and Publications|
|UMIN-ID : This clinical trial is registered in UMIN-CTR (Medical Information, University hospital Medical Information Network - Clinical Trials Registry). Please search for this trial by UMIN-ID in the following URL.|
|Memo||Protocol was revised to ver1.1 on Oct.3,2016|
JBCRG-22(Neo Entrance) :
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